Molecular analysis of anti-proliferative effects against cancer cells treated with phytochemicals derived from cruciferous vegetables for development of novel molecular-targeting combinatory strategy for cancer prevention

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To achieve desirable effects of dietary phytochemicals on cancer prevention, studies on effective combinations of phytochemicals and the molecular mechanisms might contribute to chemopreventive strategies. This study shows the anti-proliferative effects of components of the cruciferous vegetables believed to be useful for cancer prevention. In addition, combinations of indole-3-carbinol, one component of cruciferous vegetables, with genistein contained in soy or galangin contained in propolis were also shown to be effective for inhibition of growth of cancer cells accompanied with inhibition of autophagic process or accumulation of reactive oxygen species (ROS), respectively.