Elucidation of the mechanism of developing cardiovascular disease by job stress : a multi-biomarker assessment.

本研究的目的是阐明工作压力增加心血管疾病风险的机制，通过询问工作压力和测量几个生化指标和肱动脉硬度指数作为生理指标，在2个工作场所。N-末端前B型利钠肽（NT-proBNP），心脏应激的标志物，和工作控制之间存在显著的负相关。此外，肱动脉僵硬度的标志物--体积弹性模量（VE）与“我感到愤怒”显著相关。”“我的内心很烦躁。”和“我不能做任何工作。“在工作中的心身状态问题中。这些结果增加了工作压力增加心脏压力和损害肱动脉特性的可能性。NT-proBNP和VE的测量也可能有助于评估工作压力引起的心血管风险。

The purpose of the present research was to elucidate the mechanisms by which job stress increases the risk of cardiovascular disease, by asking job stress and by measuring several biochemical markers and brachial artery stiffness indices as physiological markers in 2 workplaces. There was a significant negative correlation between N-terminal pro B type natriuretic peptide(NT-proBNP), a marker of cardiac stress, and job control. In addition, the volume elastic modulus(VE), a marker of brachial artery stiffness, was significantly correlated with "I feel anger.""I am irritating on the inside.", and "I cannot do any work." among the questions about the psychosomatic state during working. These results raise the possibility that job stress increases cardiac stress and impairs brachial artery properties. The measurement of NT-proBNP and VE may also be useful for evaluating cardiovascular risk caused by job stress.