Molecule epidemiology research on genetic polymorphisms of DNA repair enzyme and colorectal cancer

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On the analysis of polymorphisms of single strand break repair enzyme XRCC1 gene (Arg194Trp, Arg280His, and Arg399Gln) and colorectal cancer risk, the399Gln/Gln genotype was associated with an increased risk of colorectal cancer, and the increased risk was more remarkable in individuals with these genotype and high alcohol consumption. XRCC3 Thr241Met and XRCC4 which are double strand-break repair enzyme gene polymorphism were also examined. The interaction of these gene polymorphisms and alcohol consumption for colorectal cancer risk was shown. The above result has suggested that DNA repair enzyme gene polymorphisms has played the role important for colorectal carcinogenesis in relation to alcohol consumption.