Molecule epidemiology research on genetic polymorphisms of DNA repair enzyme and colorectal cancer

DNA修复酶基因多态性与结直肠癌的分子流行病学研究

• 批准号: 21790584
• 负责人: YIN Guang
• 金额: $ 2.41万
• 依托单位: Nagoya University (2010)Kyushu University (2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790584/
• 关键词: 大腸がん; DNA修復酵素遺伝子多型; 分子疫学; 症例対照研究

On the analysis of polymorphisms of single strand break repair enzyme XRCC1 gene (Arg194Trp, Arg280His, and Arg399Gln) and colorectal cancer risk, the399Gln/Gln genotype was associated with an increased risk of colorectal cancer, and the increased risk was more remarkable in individuals with these genotype and high alcohol consumption. XRCC3 Thr241Met and XRCC4 which are double strand-break repair enzyme gene polymorphism were also examined. The interaction of these gene polymorphisms and alcohol consumption for colorectal cancer risk was shown. The above result has suggested that DNA repair enzyme gene polymorphisms has played the role important for colorectal carcinogenesis in relation to alcohol consumption.

在单链断裂修复酶XRCC1基因(Arg194Trp、Arg280His和Arg399Gln)与结直肠癌风险的分析中，399Gln/Gln基因与结直肠癌的风险增加有关，并且在高饮酒和这些基因的个体中风险增加更为显著。还检测了双链断裂修复酶基因XRCC3、Thr241Met和XRCC4的多态性。这些基因多态和饮酒与结直肠癌风险的交互作用被显示出来。以上结果提示，DNA修复酶基因多态性与饮酒有关，在结直肠癌的发生中起重要作用。

项目成果

XRCC1遺伝子多型と大腸がん:福岡大腸がん研究

XRCC1基因多态性与结直肠癌：福冈结直肠癌研究

• 发表时间: 2010
• 作者: 古川慎哉;恩地森一;他;銀光;古川慎哉;銀光
• 通讯作者: 銀光

XRCC1遺伝子多型と大腸がん,福岡大腸がん研究

XRCC1基因多态性与结直肠癌，福冈结直肠癌研究

• 发表时间: 2010
• 作者: 古川慎哉;恩地森一;他;銀光
• 通讯作者: 銀光