Elucidation of Toxicokinetics/Toxicodinamics(TK/TD) of haloperidol in sever fatty liver rats.

氟哌啶醇在严重脂肪肝大鼠中的毒代动力学/毒理学（TK/TD）阐明。

• 批准号: 21790607
• 负责人: IKEMURA Mayumi
• 金额: $ 2.83万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790607/
• 关键词: 薬物中毒; 脂肪肝; ハロペリドール; トキシコロジー; 薬物代謝; 臓器分布

The aim of this study was to investigate the difference in the pharmacokinetics of haloperidol between rats with fatty livers(FL) and those with normal livers(NL). The therapeutic dosage and an overdose of haloperidol were administrated to rats with normal and severe fatty liver. The concentrations in both blood and organs of haloperidol in FL were significantly higher than in NL at the therapeutic dosage, while there was no significant difference between FL and NL in the blood and organ concentrations of haloperidol at the overdose dosage. Additionally, the volume of portal vein blood flow significantly increased after the overdose administration compared with pre-administration and therapeutic dosage in NL, whereas it did not change after the overdose or the therapeutic dosage administration compared with pre-administration in FL, although it was significantly higher than in NL. The metabolism might have been already saturated before the administration of haloperidol in FL, so it is possible that the blood concentration of haloperidol tends to be much higher in the individuals with FL than in those with NL in inverse proportion to the dosage amount of haloperidol.

本研究的目的是探讨氟哌啶醇在脂肪肝（FL）大鼠和正常肝（NL）大鼠体内药代动力学的差异。对正常和重度脂肪肝大鼠分别给予治疗剂量和过量氟哌啶醇。在治疗剂量下，FL的血药浓度和脏器浓度均显著高于NL，而在过量剂量下，FL和NL的血药浓度和脏器浓度无显著性差异。此外，NL中，与给药前和治疗剂量相比，过量给药后门静脉血流量显著增加，而FL中，与给药前相比，过量或治疗剂量给药后门静脉血流量没有变化，尽管其显著高于NL。FL患者在氟哌啶醇给药前代谢可能已经饱和，因此FL患者的氟哌啶醇血药浓度可能远高于NL患者，与氟哌啶醇的剂量成反比。

项目成果

三重沿岸における珪藻類の分布および変動の解析.

三重沿岸硅藻的分布和变化分析。

• 发表时间: 2010
• 期刊: 法医学の実際と研究 53
• 作者: 篠根光太郎;西垣戸麻美;岡田華奈;中川泰久;池村真弓;井上裕匡;那谷雅之
• 通讯作者: 那谷雅之

脂肪肝病態時におけるcyp3A活性変動

脂肪肝病理过程中 cyp3A 活性的变化

• 发表时间: 2009
• 作者: 池村真弓;西垣戸麻美;篠根光太郎;中川泰久;神谷宗親;岡田華奈;那谷雅之
• 通讯作者: 那谷雅之

脂肪肝モデルラットにおける抗精神病薬ハロペリドールの体内動態および臓器蓄積性の検討(第2報)

抗精神病药氟哌啶醇在脂肪肝模型大鼠体内的药代动力学及器官蓄积研究（第二报）

• 发表时间: 2010
• 作者: 池村真弓;岡田華奈;篠根光太郎;中川泰久;井上裕匡;那谷雅之
• 通讯作者: 那谷雅之

脂肪肝業態時における代謝酵素cyp3a活性変動

脂肪肝状态下代谢酶 cyp3a 活性的变化

• 发表时间: 2009
• 作者: 池村真弓;岡田華奈;篠根光太郎;中川泰久;井上裕匡;那谷雅之;水尾圭祐;池村真弓;池村真弓;Keisuke Mizuo;池村真弓
• 通讯作者: 池村真弓

Cerebral infarction due to aortic dissection which developed immediately after traffic accident.

交通事故后立即发生的主动脉夹层导致脑梗塞。

• 发表时间: 2010
• 期刊: J Forensic Leg Med. 17(4)
• 作者: Inoue H;Nakagawa Y;Ikemura M;Shinone K;Nata M.
• 通讯作者: Nata M.