Development of novel alternative approach for liver cirrhosis therapy using adipose-derived stem cells

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The purpose in the present study was to investigate the effectiveness of adipose-derived stem cell(ADSC) transplantation into skeletal muscle as novel alternative therapy for liver cirrhosis in mouse. Human ADSC was transplanted into the gastrocnemius muscle in nude mouse, and then, the mouse received the repetitional injections of CCl_4 to induce liver damage and fibrosis. In the ADSC-transplanted mice, serum levels of albumin and total protein were kept at higher than in the control mice. Spleen index(tissue weight/body weight) were significantly lower in the ADSC mice than the control, and other skeletal muscle weights per body weight were also maintained in the ADSC mice. The protein expression of alpha-smooth muscle actin as a parameter of fibrosis was also lower in the ADSC mice than the control. The present study suggested a possibility that the transplantation of ADSC into skeletal muscle would be one of novel strategies for alternative therapy to the patients with liver cirrhosis.