Costraction of full-length lymphotropic HCV strain and immunopathogenesis of HCV lymphotropism

结果表明，源自B细胞淋巴瘤的嗜淋巴型HCV （SB-HCV）不仅能在淋巴瘤细胞系中复制，而且能在人原代淋巴细胞中复制，尤其是在B细胞和CD45RA+RO-naive T细胞中。SB-HCV株可感染未成熟的CD4+细胞并抑制其增殖活性。我们已经发现hcv核心蛋白是能够阻断STAT-1信号传导的负责蛋白。

It was shown that lymphotropic HCV (SB-HCV strain) derived from B cell lymphoma could not only replicate in lymphoma-cell-lines but also in primary human lymphocyte especially B cells and CD45RA+RO-naive T cells. SB-HCV strain could infect naive CD4+ cells and suppress the activity of proliferation. We have found that HCV-core protein is responsible protein that could block STAT-1 signaling.