WT1-specific immunological assessments in WT1-peptide-based cancer vaccine in combination with gemcitabine for patients with advanced pancreatic cancer

基于 WT1 肽的癌症疫苗联合吉西他滨治疗晚期胰腺癌患者的 WT1 特异性免疫学评估

• 批准号: 21790665
• 负责人: NISHIDA Sumiyuki
• 金额: $ 2.58万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790665/
• 关键词: 胆道学; 膵臓学(膵臓癌); 膵臓癌; WT1; 癌免疫療法; 細胞傷害性リンパ球; 細胞障害性リンパ球

A clinical study of WT1-peptide-based cancer vaccine(WT1 vaccine) in combination with gemcitabine was performed for the patients with advanced pancreatic cancer. I focused on the association between clinical efficiency and WT1-specific immunological monitoring, such as i) delayed-type hypersensitivity(DTH) to WT1 peptide and ii) WT1-specific cytotoxic lymphocytes in the peripheral blood(WT1-CTLs). An association between longer survival and DTH-positivity was statistically significant, and longer survivors had higher frequency of WT1-CTLs with memory phenotype.

WT1肽癌症疫苗（WT1疫苗）联合吉西他滨对晚期胰腺癌患者进行了临床研究。我重点关注临床效率与 WT1 特异性免疫监测之间的关联，例如 i) 对 WT1 肽的迟发型超敏反应 (DTH) 和 ii) 外周血中的 WT1 特异性细胞毒性淋巴细胞 (WT1-CTL)。较长的生存期与 DTH 阳性之间的关联具有统计学意义，并且较长的生存期具有较高的具有记忆表型的 WT1-CTL 频率。

项目成果

Memory WT1-CTLs is a useful marker to predict the clinical outcome ; WT1 vaccine in the combination with gemcitabine

记忆 WT1-CTL 是预测临床结果的有用标记；

• 发表时间: 2011
• 作者: Oji Y;Oka Y;Nishida S;et al;西田純幸;西田純幸;Nishida S
• 通讯作者: Nishida S

WT1ペプチドワクチン療法の癌に対する集学的治療への仲間入りを目指した臨床研究

旨在将 WT1 肽疫苗疗法添加到多学科癌症治疗中的临床研究

• 发表时间: 2010
• 作者: 土谷博之;他;西田純幸
• 通讯作者: 西田純幸

Cancer immunotherapy combined with chemotherapy for pancreatic cancer ; a phase 1 clinical trial of the combination therapy with gemcitabine and WT1-peptide-based cancer vaccine

癌症免疫治疗联合化疗治疗胰腺癌；

• 发表时间: 2011
• 作者: Oji Y;Oka Y;Nishida S;et al;西田純幸;西田純幸;Nishida S;Nishida S;S. Nishida
• 通讯作者: S. Nishida

WT1 PEPTIDE-BASED CANCER VACCINE IN COMBINATION WITH GEMCITABINE IN PATIENTS WITH ADVANCED PANCREATIC CANCER-PHASE 1 CLINICAL TRIAL-

WT1 基于肽的癌症疫苗与吉西他滨联合治疗晚期胰腺癌患者 - 第一阶段临床试验 -

• 发表时间: 2011
• 作者: Oji Y;Oka Y;Nishida S;et al;西田純幸;西田純幸;Nishida S;Nishida S;S. Nishida;Nishida S;S. Nishida;Nishida S
• 通讯作者: Nishida S

WT1 Peptide Therapy for a Patient with Chemotherapy-resistant Salivary Gland Cancer

WT1 肽治疗化疗耐药唾液腺癌患者

• 发表时间: 2012
• 期刊: Anticancer Res
• 影响因子: 2
• 作者: Shirakata T;Oka Y;Nishida S;et al
• 通讯作者: et al