Elucidation of the basic mechanism of angiogenesis and cardiomyocyte regeneration induced by the external shockwaves.

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We demonstrated that the shockwave treatment applied to cultured human umbilical vein endothelial cells up-regulated mRNA expression of vascular endothelial growth factor, although further studies are required to determine the optimal condition of the shockwave treatment. Extracorporeal shockwave therapy applied to a rat experimental model of chronic heart failure induced a tendency to improve a left ventricular contractile function and a survival rate as well as a significant increase of capillary density in myocardium.