Investigation of the intracellular signaling induced by the SUMO modification in the process of CHF

CHF过程中SUMO修饰诱导的细胞内信号传导研究

• 批准号: 21790701
• 负责人: SHISHIDO Tetsuro
• 金额: $ 2.75万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790701/
• 关键词: 慢性心不全; 糖尿病; SUMOylation

Clarify the mechanisms by which aging and diabetes are independent factor for the advancing the heart failure after myocardial infarction contribute to find a new therapeutic target for chronic heart failure. As shown in previous reports using animal model, we found that oxidative stress is increased in patients with heart failure, moreover, its concentration is associated with the severity and prognosis. We found the important role of DGKalpha, which exist in human heart but not in mice, in the process of ischemia reperfusion injury. We also found that oxidative stress modulated the kinase cascade, and modulated the SUMOylation and ubiquitination, finally induced myocardial injury.

阐明衰老和糖尿病是心肌梗死后心力衰竭进展的独立因素的机制，有助于寻找慢性心力衰竭的新治疗靶点。正如之前的动物模型报告所示，我们发现心力衰竭患者的氧化应激水平升高，而且其浓度与心力衰竭的严重程度和预后相关。我们发现DGKα在缺血再灌注损伤过程中发挥重要作用，DGKα存在于人类心脏中，但不存在于小鼠心脏中。我们还发现氧化应激调节激酶级联反应，并调节SUMO化和泛素化，最终诱导心肌损伤。

项目成果

Combination of pentosidine and carboxy-terminal telopeptide of type I collagen strongly predicts cardiac events in heart failure patients with preserved left ventricular ejection fraction.

戊糖素和 I 型胶原羧基末端端肽的组合可以强烈预测左心室射血分数保留的心力衰竭患者的心脏事件。

• 发表时间: 2010
• 作者: Funayama A;Shishido T;Ohtaki Y;Hasegawa H;Honda S;Netsu S;Ishino M;Arimoto T;Takahashi H;Miyashita T;Miyamoto T;Nitobe J;Watanabe T;Kubota I
• 通讯作者: Kubota I

Influence of diabetes mellitus on prognostic utility of cardiac iodine-123-metaiodobenzylguanidine in diastolic heart failure patients.

糖尿病对心脏碘-123-间碘苄胍对舒张性心力衰竭患者预后效用的影响。

• 发表时间: 2010
• 作者: Katoh S;Shishido T;Kutsuzawa D;Arimoto T;Watanabe T;Kubota I
• 通讯作者: Kubota I

Iodine-123-Metaiodobenzyl Guanidine Imaging Can Predict Future Cardiac Events in Patients With Preserved Heart Failure

碘-123-间碘苄基胍成像可以预测保留性心力衰竭患者未来的心脏事件

• 发表时间: 2009
• 作者: Suzuki S;Shishido T;Sasaki T;Kato S;Ishino M;Watanabe T;Takeishi Y;Kubota I;Akira Funayama;Daisuke Kutsuzawa;Satoshi Suzuki;Toshiki Sasaki;Shigehiko Katoh;Satoshi Nishiyama;Harutoshi Tamura;Shigehiko Katoh
• 通讯作者: Shigehiko Katoh

High Serum Level of Neopterin Predicts Cardiac Events in Chronic Heart Failure Patients With Preserved Left Ventricular Systolic Function

高血清新蝶呤水平可预测左心室收缩功能保留的慢性心力衰竭患者的心脏事件

• 发表时间: 2009
• 作者: Suzuki S;Shishido T;Sasaki T;Kato S;Ishino M;Watanabe T;Takeishi Y;Kubota I;Akira Funayama;Daisuke Kutsuzawa;Satoshi Suzuki;Toshiki Sasaki;Shigehiko Katoh;Satoshi Nishiyama;Harutoshi Tamura;Shigehiko Katoh;Changhoon Woo;Satoshi Suzuki;Toshiki Sasaki
• 通讯作者: Toshiki Sasaki

Critical role of p90RSK on ERK5-SUMOylation in development of LV dysfunction in diabetic heart after myocardial infarction

p90RSK 对 ERK5-SUMO 化在糖尿病心脏心肌梗死后左室功能障碍发展中的关键作用

• 发表时间: 2010
• 作者: Kitahara T;et al;Tamura H;Shishodo T;宍戸哲郎;Tetsuro Shishido
• 通讯作者: Tetsuro Shishido