Identification of MURC, muscle-restricted coiled-coil protein, and molecular characterization of MURC-induced cardiac dysfunction and arrhythmia

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We identified a muscle-restricted coiled-coil protein, MURC, and found that MURC was localized to caveolae at the plasma membrane of cardiomyocytes and was associated with caveolin-3, PTRF/cavin-1, SDPR/cavin-2, and SRBC/cavin-3. We also found that overexpression of MURC in cardiomyocytes induced distension of caveolae and transgenic mice expressing MURC in the heart exhibited deformation of caveolae in cardiomyocytes. Since transgenic mice expressing MURC in the heart shows cardiac dysfunction and arrhythmia, we are investigating the molecular mechanisms responsible for MURC-induced cardiac dysfunction and arrhythmia.