Investigation of mechanism of acute exacerbation of interstitial pneumonia. Alveolar barrier dysfunction was observed in fibrotic lung

间质性肺炎急性加重机制探讨

• 批准号: 21790764
• 负责人: OHTA Hiromitsu
• 金额: $ 2.75万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790764/
• 关键词: 間質性肺炎; 肺障害; ARDSタイトジャンクション; 非閉塞性肺疾患; 肺線維症; タイトジャンクション

One of the pathological change of pneumonia, heart failure, and ARDS is thought to be a failure of barrier function of alveolar epithelial cells. We used bleomycin-induced pulmonary fibrosis model. After administration of bleomycin, expressions of tight junction-related proteins, especially claudin-5 and claudin-18 were down-regulated. We also analyzed the influence of transforming growth factor-β (TGF-β), a critical mediator of pulmonary fibrosis on tight junctions in vitro. The addition of TGF-β disrupted expressions of claudins. These results suggest that bleomycin-induced lung injury causes pathogenic alterations in tight junctions and that such alterations seem to be induced by TGF-β.

肺炎、心力衰竭、ARDS的病理变化之一是肺泡上皮细胞屏障功能的丧失。采用博莱霉素诱导的肺纤维化模型。博莱霉素处理后，紧密连接相关蛋白表达下调，尤其是claudin-5和claudin-18。我们还分析了转化生长因子-β（TGF-β），肺纤维化的关键介质对紧密连接的影响。TGF-β的加入破坏了claudins的表达。这些结果表明，博莱霉素诱导的肺损伤引起紧密连接的致病性改变，并且这种改变似乎是由TGF-β诱导的。

项目成果

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Lung Cancer in Patients with Pulmoanry Fibrosis

肺纤维化患者的肺癌

• 发表时间: 2010
• 作者: Hiromitsu Obta;et al
• 通讯作者: et al

The Disappearance of Subpleural and Interlobular Lymphatics in Idiopathic Pulmonary Fibrosis

• DOI: 10.1089/lrb.2010.0008
• 发表时间: 2010-01-01
• 期刊: LYMPHATIC RESEARCH AND BIOLOGY
• 影响因子: 1.4
• 作者: Ebina, Masahito;Shibata, Naoko;Nukiwa, Toshihiro
• 通讯作者: Nukiwa, Toshihiro

Gradual increase of high mobility group protein B1 (HMGB1) in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis.

特发性肺纤维化急性加重后，肺部高迁移率族蛋白 B1 (HMGB1) 逐渐增加。

• 发表时间: 2011
• 期刊: Pulmonary Medicine
• 影响因子: 4.3
• 作者: Ebina M;Taniguchi H;Miyasho T;Yamada S;Shibata N;Ohta H;Hisata S;Hirota N;Nishimura H;Ishizaka A;Maruyama I;Takashi K;Nukiwa T.
• 通讯作者: Nukiwa T.

A normal range of KL-6/MUC1 independent elevated SP-D indicates a better prognosis in idiopathic pulmonary fibrosis.

KL-6/MUC1 独立升高的 SP-D 处于正常范围表明特发性肺纤维化的预后较好。

• 发表时间: 2011
• 期刊: Pulmonary Medicine
• 影响因子: 4.3
• 作者: Hisata S;Kimura Y;Shibata N;Ono S;Kobayashi T;Chiba S;Ohta H;Nukiwa T;Ebina M.
• 通讯作者: Ebina M.