The effect of 5-aminoimidazole-4-carboxamide ribonucleoside (AMPK)on malignant mesothelioma cell growth and survival interval in an implant animal model of malignant mesothelioma

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In vitro, AICAR treatment significantly impaired the cell proliferation rate of malignant mesothelioma (MM)cell lines. In vivo, treatment with AICAR significantly decreased the growth rate of MM, which was accompanied by an increase in p53/phosphor-p53 levels, and down-regulated protein levels of phosphor-Akt and p70/phosphor-p70. Similar intracellular pathways are also observed in vitro experiment. These effects partly involved induction of growth arrest and apoptosis to MM cells. AICAR treatment activated AMPK. Finally, AICAR treatment also significantly extended survival interval in an implant animal model of MM. These findings suggested that AICAR or the induction of AMPK activity is an important tactic for developing therapeutic strategies against MM.