Analysis of Severe Influenza Pneumonia -Control of Host and Pathogen Factors in Influenza and Bacteria Co-infected Mice Models

我们研究了严重流感病毒相关肺炎的发病机制。在致病因子中，缺失了假单胞菌群体感应相关基因，并将其感染小鼠。毒素均有所降低，但体内差异不显著。但在病毒和链球菌混合感染的小鼠中检测到了细胞凋亡，而单独感染流感病毒的TLR相关基因缺失的小鼠则出现了过度的炎症和细胞因子风暴所致的肺水肿。过度炎症可能与重症肺炎的进展有关。

We examined the mechanisms of severe influenza virus-related pneumonia. In pathogens factor, quorum sensing related genes were deleted in Pseudomonas, and we infected them to mice. Toxin were decreased, but no significant differences were found in vivo. However, apoptosis were detected in virus and Streptococcus co-infected mice, and excessive inflammation and pulmonary edema according to cytokine storm were observed in TLR-related genes-deleted mice by influenza virus infection alone. Excessive inflammation might be related to progression of severe pneumonia