Sympathoexcitation by brain oxidative stress in hypertension associated with metabolic syndrome and chronic kidney disease
Sympathoexcitation by brain oxidative stress in hypertension associated with metabolic syndrome and chronic kidney disease
批准号:
21790797
负责人:
FUJITA Megumi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We have demonstrated that sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in chronic kidney disease(CKD) model, high salt-loaded uninephrectomized Sprague-Dawley rats. In CKD rats, responses of renal sympathetic nerve to acute intracerebroventricular(ICV) tempol and hypothalamic oxidative stress level were significantly increased. Moreover, chronic ICV tempol showed sympathoinhibitory and depressor effect, along with improvement of renal function.
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DOI:
10.1152/ajprenal.00691.2010
发表时间:
2011-06-01
期刊:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
影响因子:
4.2
作者:
[Kawarazaki, Hiroo, Ando, Katsuyuki, Fujita, Toshiro]
通讯作者:
Fujita, Toshiro
肥満高血圧における脳内酸化ストレス・交感神経系活動亢進はインスリン抵抗性改善により抑制される
肥胖和高血压患者的脑氧化应激和交感神经系统过度活跃可通过改善胰岛素抵抗来抑制。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[堀田晶子, 関常司, 他, 藤田恵]
通讯作者:
藤田恵
Reactive Oxygen Species and the Central Nervous System in Salt-sensitive Hypertension : Possible Relationship to Obesity-induced Hypertension.
盐敏感性高血压中的活性氧和中枢神经系统:与肥胖引起的高血压的可能关系。
DOI:
--
发表时间:
2011
期刊:
Clinical & Experimental Pharmacology and Physiology
影响因子:
2.9
作者:
[Ishikawa A, Kawarazaki H, Ando K, Fujita M, et al, 安東克之]
通讯作者:
安東克之
脳内酸化ストレスを介した中枢交感神経活動亢進が慢性腎臓病の病態に関与している
脑氧化应激介导的中枢交感神经活动参与慢性肾病的病理学
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[原章規, ほか, 藤田恵]
通讯作者:
藤田恵
DOI:
10.1161/hypertensionaha.111.182923
发表时间:
2012-01-01
期刊:
HYPERTENSION
影响因子:
8.3
作者:
[Fujita, Megumi, Ando, Katsuyuki, Fujita, Toshiro]
通讯作者:
Fujita, Toshiro
共 16 条
FRET/ BRET analysis of interaction between HCV protein and interferon signaling
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批准号:21590831
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.66万
-
财政年份:2009
-
负责人:FUJITA Megumi
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依托单位:
Dietary, Lifestyle and Lactation with the Menstruation in Puerperium : A Eighteen-month Follow-up Study in Miyagi Prefecture
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批准号:20592601
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.16万
-
财政年份:2008
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负责人:FUJITA Megumi
-
依托单位:
Central mechanism in hypertension-Sympathoexcitation by oxidative stress in the brain
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批准号:19790575
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.32万
-
财政年份:2007
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负责人:FUJITA Megumi
-
依托单位: