The significance of cardio-renal interaction via the rapid signal transduction system of peroxisome proliferator-activated receptorγ

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Thiazolinediones (TZDs), the medical drug used for the treatment of diabetes, have the side-effects of edema and congestive heart failure. We have investigated the mechanism of this side-effect by physiological studies and assays of proteins with culture cells and the kidneys of rats and mice. We found that TZDs enhance sodium reabsorption from renal proximal tubules via rapid signal transduction system, independently of transcription system. This may lead to develop new drugs for diabetes that do not have such side effects. (Cell Metabolism 13(5), pp.550-561, 2011)