The role of nuclear hormone receptor LXR on the pathogenesis of diabetic nephropathy
The role of nuclear hormone receptor LXR on the pathogenesis of diabetic nephropathy
批准号:
21790813
负责人:
OGAWA Daisuke
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
Several studies have reported that activation of LXR is atheroprotective; however, the role of LXR in renal function remains unclear. Here, we report the renoprotective effects of LXR activation in a model of streptozotocin-induced diabetic nephropathy. These findings uncover a previously unrecognized mechanism for the renoprotective effects of LXR agonists and support the concept that LXR agonists may offer a novel therapeutic approach for the treatment of diabetic nephropathy.
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Emphysematous cystitis in a patient with type-2 diabetes mellitus.
2 型糖尿病患者的肺气肿性膀胱炎。
DOI:
10.4103/2230-8210.83051
发表时间:
2011-07
期刊:
Indian journal of endocrinology and metabolism
影响因子:
--
作者:
[Gangadhar P, Gogate YV, Walia R, Bhansali A]
通讯作者:
Bhansali A
CKDと心血管病を理解する
了解 CKD 和心血管疾病
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[小川大輔, 槇野博史]
通讯作者:
槇野博史
Intercellular adhesion molecule-1 plays a critical role for glomeruloscrelosis after subtotal nephrectomy.
细胞间粘附分子-1在肾大部切除术后肾小球硬化中起关键作用。
DOI:
--
发表时间:
2011
期刊:
Clin Exp Nephrol 15
影响因子:
--
作者:
[Kido Y*, Ogawa D*, Shikata K, Sasaki M, Nagase R, Okada S, Usui-Kataoka H, Wada J, Makino H.]
通讯作者:
Makino H.
糖尿病性腎症におけるPPARδアゴニストの有効性の検討
PPARδ激动剂治疗糖尿病肾病的有效性检查
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[松下裕一, 小川大輔, 佐藤千景, 和田淳, 四方賢一, 槇野博史]
通讯作者:
槇野博史
DOI:
10.2337/db09-1894
发表时间:
2011-01
期刊:
Diabetes
影响因子:
7.7
作者:
[Sato C, Shikata K, Hirota D, Sasaki M, Nishishita S, Miyamoto S, Kodera R, Ogawa D, Tone A, Kataoka HU, Wada J, Kajitani N, Makino H]
通讯作者:
Makino H
共 14 条
The role of nuclear hormone receptor PPARδon the pathogenesis of diabetic nephropathy
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批准号:23790942
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
-
财政年份:2011
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负责人:OGAWA Daisuke
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依托单位:
海外基金