Contribution of (pro)renin receptor to the development of insulin resistance in obese hypertension

肾素（原）受体对肥胖高血压胰岛素抵抗发展的贡献

• 批准号: 21790820
• 负责人: KAMAYACHI Tadashi
• 金额: $ 2.75万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790820/
• 关键词: (プロ)レニン受容体; メタボリックシンドローム; インスリン抵抗性

We studied the influence of insulin resistance when we administered obese and lean hypertensive rats (pro) renin receptor blocker, the decoy and its scramble for 12 weeks. Intraperitoneal glucose tolerance test results in obese was higher than lean in the glucose level in the untreated group. The scramble treatment group had no change in blood glucose, but the decoy treatment group was improved. The intraperitoneal insulin tolerance test compared before and after administration of insulin to glucose levels after administration of insulin in 90 minutes and in 120 minutes. The scramble treatment did not improve lowering blood glucose levels, but the decoy treatment improved. The obese decoy treatment group had increased the skeletal muscle Ark phosphorylation more than the obese untreated group.

我们研究了肥胖和瘦瘦型高血压大鼠(PRO)给予肾素受体阻滞剂、诱饵及其拮抗剂12周后对胰岛素抵抗的影响。腹膜糖耐量试验结果显示，肥胖组血糖水平高于瘦肉组。抢救治疗组血糖无明显变化，诱骗治疗组血糖有所改善。腹膜胰岛素耐量试验比较给药前后、给药后90min和120min的血糖水平。抢救治疗并未改善降血糖水平，但诱骗治疗有所改善。肥胖诱饵治疗组大鼠骨骼肌ARK磷酸化水平明显高于肥胖未治疗组。

项目成果

Contribution of (pro) renin receptor to the development of insulin resistance in obese hypertensive rats

肾素（原）受体对肥胖高血压大鼠胰岛素抵抗发展的贡献

• 发表时间: 2010
• 作者: 塚田愛;木村徹;Promsuk Jutabha;安西尚彦;市田公美;櫻井裕之;釜萢正
• 通讯作者: 釜萢正

Contribution of (pro)renin receptor to the development of insulin resistance in obese hypertensive rats

肾素（原）受体对肥胖高血压大鼠胰岛素抵抗发展的贡献

• 发表时间: 2010
• 作者: 塚田愛;木村徹;Promsuk Jutabha;安西尚彦;市田公美;櫻井裕之;釜萢正;釜萢正
• 通讯作者: 釜萢正

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