Establishment of objective evaluation of neuropathic pain based on axonal ionic pathophysiology

周围神经损伤改变轴膜电压门控钠离子通道的功能和表达，导致异位放电和神经病理性疼痛。我们用计算机阈值跟踪系统研究了人感觉神经轴突结节持续Na~+电流的变化。神经病理性疼痛与Na~+电流的增加显著相关，并可被Na~+通道阻滞剂与Na~+电流降低相关的应用所抑制。客观疼痛程度可通过阈值跟踪系统进行评估。

Peripheral nerve injury alters function and expression of voltage gated Na^+ channels on the axolemma, leading to ectopic firing and neuropathic pain. We investigated changes in nodal persistent Na^+ currents in human sensory axons using computerized threshold tracking system. Neuropathic pain was significantly associated with increased Na^+ currents and was suppressed by administration of Na^+ channel blocker associated with decreased Na^+ currents. Objective degree of pain could be evaluated by threshold tracking system.