Establishment of objective evaluation of neuropathic pain based on axonal ionic pathophysiology

基于轴突离子病理生理学的神经病理性疼痛客观评价方法的建立

• 批准号: 21790834
• 负责人: MISAWA Sonoko
• 金额: $ 2.75万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790834/
• 关键词: 軸索機能検査法; 軸索Na電流; 神経原性疼痛; 糖尿病性末梢神経障害; Naチャネル阻害薬

Peripheral nerve injury alters function and expression of voltage gated Na^+ channels on the axolemma, leading to ectopic firing and neuropathic pain. We investigated changes in nodal persistent Na^+ currents in human sensory axons using computerized threshold tracking system. Neuropathic pain was significantly associated with increased Na^+ currents and was suppressed by administration of Na^+ channel blocker associated with decreased Na^+ currents. Objective degree of pain could be evaluated by threshold tracking system.

周围神经损伤改变了轴膜上电压门控Na^+通道的功能和表达，导致异位放电和神经病理性疼痛。我们用计算机阈值跟踪系统研究了人感觉神经轴突节持续性Na^+电流的变化。神经病理性疼痛与Na^+电流增加显著相关，给予Na^+通道阻滞剂可抑制神经病理性疼痛，同时降低Na^+电流。疼痛的客观程度可通过阈值跟踪系统进行评估。

项目成果

Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain

• DOI: 10.1016/j.clinph.2009.12.034
• 发表时间: 2010-05-01
• 期刊: CLINICAL NEUROPHYSIOLOGY
• 影响因子: 4.7
• 作者: Isose, Sagiri;Misawa, Sonoko;Kuwabara, Satoshi
• 通讯作者: Kuwabara, Satoshi

Altered axonal excitability properties injuvenile muscular atrophy of distal upperextremity (Hirayama disease)

上肢远端幼年性肌萎缩症（平山病）轴突兴奋性特性改变

• DOI: 10.1016/j.clinph.2010.06.015
• 发表时间: 2011
• 期刊: ClinNeurophysiol
• 作者: Sawai S;Misawa S;Kanai K;Isose S,Shibuya K;Noto Y;Fujimaki Y;SekiguchiY;Nasu S;Nomura F;Kuwabara S.
• 通讯作者: Kuwabara S.

Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: Specificity, sensitivity, and a possible prognostic value

• DOI: 10.3109/17482968.2010.541263
• 发表时间: 2011-03-01
• 期刊: AMYOTROPHIC LATERAL SCLEROSIS
• 作者: Noto, Yu-Ichi;Shibuya, Kazumoto;Kuwabara, Satoshi
• 通讯作者: Kuwabara, Satoshi

Electrophysiology in hemifacial spasm

面肌痉挛的电生理学

• 发表时间: 2010
• 作者: Kuwabara S;Kokubun N;Misawa S;Kanai K;Isose S;Shibuya K;Noto Y;Mori M;Sekiguchi Y;Nasu S;Fujimaki Y;Hirata K;Yuki N.;金井数明;澤井摂;Misawa S.
• 通讯作者: Misawa S.

Electrophysiology in Hemifcialspasm

半身痉挛的电生理学

• 发表时间: 2010
• 作者: Kuwabara S;Kokubun N;Misawa S;Kanai K;Isose S;Shibuya K;Noto Y;Mori M;Sekiguchi Y;Nasu S;Fujimaki Y;Hirata K;Yuki N.;金井数明;澤井摂;Misawa S.;澤井摂;Misawa S.
• 通讯作者: Misawa S.