Establishment of objective evaluation of neuropathic pain based on axonal ionic pathophysiology

周围神经损伤改变了轴膜上电压门控Na^+通道的功能和表达，导致异位放电和神经性疼痛。我们使用计算机阈值跟踪系统研究了人类感觉轴突节点持续Na^+电流的变化。神经性疼痛与Na^+电流增加显著相关，并可通过给予与Na^+电流减少相关的Na^+通道阻滞剂来抑制。用阈值跟踪系统评价客观疼痛程度。

Peripheral nerve injury alters function and expression of voltage gated Na^+ channels on the axolemma, leading to ectopic firing and neuropathic pain. We investigated changes in nodal persistent Na^+ currents in human sensory axons using computerized threshold tracking system. Neuropathic pain was significantly associated with increased Na^+ currents and was suppressed by administration of Na^+ channel blocker associated with decreased Na^+ currents. Objective degree of pain could be evaluated by threshold tracking system.