The analysis of the transportation of amyloid-β peptide across the blood-brain barrier

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Alzheimer's disease (AD) is the most common cause of dementia. Although several in vivo studies suggest that the blood-brain barrier is compromised in AD brain, the underlying mechanisms remain unclear. In this study, we demonstrated that Aβ42 decreased the expression of claudin-5 and disrupted the tight junction of human brain endothelial cell lines. In addition, we examined whether efflux transporters expressed in the BBB are involved in the transportation of Aβ across the BBB. Our in vitro study suggested that ABCG2 transcytosed Aβ40 out of the brain across the blood-brain barrier.