The analysis of the stress response on glycemic control in liver
The analysis of the stress response on glycemic control in liver
肝脏应激反应对血糖控制的分析
批准号：
21790869
负责人：
NAKAMURA Kyoko
金额：
$2.66万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2010
中文摘要
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英文摘要
In this study, we analyzed the gene expression of hormone and stress related factors in liver. We found (1) down-expression of insulin-like growth factor-1 (IGF-1), (2,3) up-expression of IGF binding protein-1 (IGFBP-1) and 11β-hydroxysteroid dehydrogenase-1 (11β-HSD1), (4) the down-expression of ER stress marker and (5) the up-expression of glucagon-like peptide-1 (GLP-1) receptor in liver of type 2 diabetic model mice under the conditions of fasting and refeeding.
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