Regulatory mechanisms of lipin, a multifunctional metabolic regulator, and its therapeutic application for metabolic diseases

脂蛋白-1是一种多功能的代谢调节剂。脂肪细胞中Lipin-1的基因表达与全身糖代谢密切相关，但其机制尚不清楚。在此，我们发现肿瘤坏死因子-α通过JAK2信号抑制了3T3-L1脂肪细胞中脂蛋白-1mRNA的表达。此外，使用RNAi方法抑制Lipin-1的表达增加了脂肪细胞中单核细胞趋化蛋白-1mRNA的表达。我们的结论是，Lipin-1参与了与脂肪组织炎症相关的关键分子之一。

Lipin-1 is known as a multifunctional metabolic regulator. The gene expression of lipin-1 in adipocytes is closely related to whole body glucose metabolism, but the mechanism remains unclear. Here, we showed that TNF-α suppressed lipin-1 mRNA expression via Jak2 signal in 3T3-L1 adipocytes. Moreover, suppression of lipin-1 expression using RNAi method increases monocyte chemoattractant protein-1 mRNA expression in the adipocytes. We conclude that lipin-1 is implicated in one of crucial molecules related to adipose tissue inflammation.