Elucidation of molecular mechanisms of the leptin resistance

瘦素(L)/胰淀素(A)联合给药显著减少了瘦素抵抗饮食诱导肥胖小鼠的食物摄入量和体重，而单独给药或胰淀素(A)没有影响。L/A联合给药增强了胰岛素敏感性，降低了组织甘油三酯含量，增加了骨骼肌α2 amp活化蛋白激酶（AMPK）活性。本研究证实了L/A联合给药对DIO小鼠糖脂代谢的有益影响，提示L/A联合给药作为一种新的抗肥胖相关性糖尿病治疗方法可能具有临床应用价值。

Leptin (L)/amylin (A) co-administration significantly reduced food intake and body weight in leptin-resistant diet-induced obesity mice, while administration of L or A alone had no effects. L/A co-administration enhanced insulin sensitivity associated with decreased tissue triglyceride content and increased α2 AMP-activated protein kinase (AMPK) activity in skeletal muscle. This study demonstrates the beneficial effect of L/A co-administration on glucose and lipid metabolism in DIO mice, indicating the possible clinical usefulness of L/A co-administration as a new anti-diabetic treatment in obesity-associated diabetes.