Elucidation of molecular mechanisms of the leptin resistance

阐明瘦素抵抗的分子机制

• 批准号: 21790892
• 负责人: KUSAKABE Toru
• 金额: $ 2.75万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790892/
• 关键词: レプチン; 糖尿病; メタボリックシンドローム; 肥満; アミリン; レプチン抵抗性; 脂肪; 脂肪肝

Leptin (L)/amylin (A) co-administration significantly reduced food intake and body weight in leptin-resistant diet-induced obesity mice, while administration of L or A alone had no effects. L/A co-administration enhanced insulin sensitivity associated with decreased tissue triglyceride content and increased α2 AMP-activated protein kinase (AMPK) activity in skeletal muscle. This study demonstrates the beneficial effect of L/A co-administration on glucose and lipid metabolism in DIO mice, indicating the possible clinical usefulness of L/A co-administration as a new anti-diabetic treatment in obesity-associated diabetes.

瘦素（L）/胰淀素（A）共同施用显著降低瘦素抗性饮食诱导的肥胖小鼠的食物摄入和体重，而单独施用L或A没有效果。L/A联合给药增强了胰岛素敏感性，与组织甘油三酯含量降低和骨骼肌中α2 AMP活化蛋白激酶（AMPK）活性增加相关。本研究证明了L/A共给药对DIO小鼠中葡萄糖和脂质代谢的有益作用，表明L/A共给药作为肥胖相关糖尿病的新的抗糖尿病治疗可能具有临床用途。

项目成果

2型糖尿病におけるレプチン治療の有用性に関する検討

瘦素治疗2型糖尿病的有效性研究

• 发表时间: 2009
• 作者: Masanori Iwanishi;Toru Kusakabe;et al.;日下部徹;日下部徹;日下部徹
• 通讯作者: 日下部徹

Clinical characteristics and efficacy of pioglitazone in a Japanese diabetic patient with an unusual type of familial partial lipodystrophy

• DOI: 10.1016/j.metabol.2009.04.043
• 发表时间: 2009-12-01
• 期刊: METABOLISM-CLINICAL AND EXPERIMENTAL
• 影响因子: 9.8
• 作者: Iwanishi, Masanori;Ebihara, Ken;Nakao, Kazuwa
• 通讯作者: Nakao, Kazuwa

Irbesartan treatment up-regulates hepatic expression of PPARalpha and its target genes in obese Koletsky (fa(k)/fa(k)) rat s: a link to amelioration of hypertriglyceridaemia.

厄贝沙坦治疗上调肥胖 Koletsky (fa(k)/fa(k)) 大鼠肝脏 PPARα 及其靶基因的表达：与改善高甘油三酯血症有关。

• 发表时间: 2010
• 期刊: Br J Pharmacol. 160
• 作者: K.Ebihara;T.Kusakabe;K.Nakao.
• 通讯作者: K.Nakao.

Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons

• DOI: 10.1038/ki.2008.499
• 发表时间: 2009-02-01
• 期刊: KIDNEY INTERNATIONAL
• 影响因子: 19.6
• 作者: Kuwabara, Takashige;Mori, Kiyoshi;Nakao, Kazuwa
• 通讯作者: Nakao, Kazuwa

Irbesartan treatment up-regulates hepatic expression of PPARalpha and its target genes in obese Koletsky (fa(k)/fa(k)) rats : a link to amelioration of hypertriglyceridaemia.

厄贝沙坦治疗上调肥胖 Koletsky (fa(k)/fa(k)) 大鼠的肝脏 PPARα 及其靶基因表达：与改善高甘油三酯血症有关。

• 发表时间: 2010
• 期刊: Br J Pharmacol
• 作者: X.Rong;T.Kusakabe;et al.
• 通讯作者: et al.