Effects of iron-overload on normal hematopoiesis and disease progression of hamatological malignancies

铁过载对正常造血和血液恶性肿瘤疾病进展的影响

• 批准号: 21790914
• 负责人: TANAKA Hirokazu
• 金额: $ 2.75万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790914/
• 关键词: 過剰鉄; 造血幹細胞; ストローマ細胞; 活性酸素種; 造血器腫瘍; 造血; 鉄過剰

In this study, we conducted the analyses regarding how does excessive "free"iron affect the growth and differentiation of hematopoietic cells as well as the characteristic of hematopoietic stromal cells.In addition, we investigated the effects of iron overload on the proliferation of MDS clones and the pathological transformation of MDS. As a result, excessive iron impairs hematopoiesis through direct effects on hematopoietic cells and indirect effects mediated by stromal cells. Furthermore, iron overload may induce the selective proliferation of MDS clones during the deterioration of normal hematopoiesis and may be involved in the leukemic transformation. These results are significant to reveal the mechanism and treatment of various hematopoietic disorders in terms of iron-kinetics.

本研究分析了过量的“游离“铁对造血细胞生长、分化及造血基质细胞特性的影响，并探讨了铁超载对MDS克隆增殖及MDS病理转化的影响。因此，过量的铁通过对造血细胞的直接作用和基质细胞介导的间接作用损害造血。此外，铁超载可诱导MDS克隆在正常造血恶化过程中的选择性增殖，并可能参与白血病转化。这些结果对从铁动力学角度揭示各种造血系统疾病的机制和治疗具有重要意义。

项目成果

Myeloid neoplasm-related gene abnormalities differentially affect FLT3-ligand mediated dendritic cell differentiation from murine hematopoietic stem/progenitor cells

骨髓肿瘤相关基因异常对 FLT3 配体介导的鼠造血干/祖细胞分化树突状细胞有不同影响

• 发表时间: 2010
• 作者: Fujita J;Tanaka H;et al.
• 通讯作者: et al.

RUNX1 controls nucleotide excision repair (NER) system through transcriptional regulation of Gadd45a.

RUNX1 通过 Gadd45a 的转录调节来控制核苷酸切除修复 (NER) 系统。

• 发表时间: 2009
• 作者: Satoh S;Tanaka H;et al.
• 通讯作者: et al.

Excessive reactive iron affects both immature hematopoietic cells and stromal cells, thereby impairing total hematopoiesis.

过量的活性铁会影响未成熟的造血细胞和基质细胞，从而损害总造血功能。

• 发表时间: 2010
• 作者: Tanaka H;et al.
• 通讯作者: et al.

Essential role of an anti-apoptotic molecule Anamorsin for both intrinsic and extrinsic regulation of murine fetal liver hematopoiesis.

抗凋亡分子阿纳莫辛对小鼠胎肝造血的内在和外在调节的重要作用。

• 发表时间: 2010
• 作者: Tanimura A;Tanaka H;et al.
• 通讯作者: et al.

鉄代謝異常と内科系疾患

铁代谢紊乱和内科疾病

• 发表时间: 2009
• 作者: Miyauchi Y;Ninomiya K;Miyamoto H;Sakamoto A;Iwasaki R;Hoshi H;Miyamoto K;Hao W;Yoshida S;Morioka H;Chiba K;Kato S;Tokuhisa T;Saitou M;Toyama Y;Suda T;Miyamoto T.;田中宏和
• 通讯作者: 田中宏和