Mechanism for the secretion of phosphaturic hormone FGF23 to blood

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FGF23 is a phosphaturic hormone which is produced by bone and exerts its effects in kidney by increasing the urinary phosphate excretion. Although FGF23 is considered as a hormone, the mechanism for the regulation of its blood levels remains unclear. It is reported that treatment with a bisphosphonate, an inhibitor of bone resorption, is associated with increased levels of FGF23 in patients with osteogenesis imperfecta. Therefore, in the current study, we have tested the hypothesis by animal experiments that FGF23 produced by osteocytes is stored in bone matrix, and released to circulation in association with osteoclastic bone resorption. Administration of factors which stimulate bone resorption to mice resulted in the increased levels of serum FGF23, suggesting that osteoclastic bone resorption is involved in the secretion of FGF23 to blood.