Development of an artificial placenta using a premature lamb model

本研究的目的是开发一种以泵动静脉体外生命支持回路形式的人工胎盘，以维持胎儿循环。绵羊胎儿在人工胎盘的帮助下存活了15个多小时，同时保持了胎儿循环。多巴胺可使平均动脉压短暂升高。然而，随着时间的推移，即使维持人工胎盘的气体交换，血乳酸也会增加，心脏功能也会逐渐恶化。在我们的实验中，平均动脉压升高可能是通过全身血管收缩来实现的，由于人工胎盘流量增加，导致全身器官流量减少，导致全身循环衰竭。通过控制每个电阻来保持系统和电路循环可能是重要的。

The purpose of this study was to develop an artificial placenta in the form of a pumplessarteriovenous extracorporeal life support circuit that could maintain fetal circulation.Sheep fetuses survived for more than 15 hours with the artificial placenta while maintaining fetal circulation. Dopamine could increase the mean arterial pressure transiently. However, blood lactatewas increased and the cardiac performance was gradually deteriorated over time even while the gas exchange ofthe artificial placenta was maintained. Elevated mean arterial pressurein our experiment might be achieved by systemic vasoconstriction, which led to decreased systemic organ flowdue to increased artificial placental flow, resulted in systemic circulatory failure. It may be important to retain both systemic and circuit circulation by controlling each resistance.