Development of an artificial placenta using a premature lamb model

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The purpose of this study was to develop an artificial placenta in the form of a pumplessarteriovenous extracorporeal life support circuit that could maintain fetal circulation.Sheep fetuses survived for more than 15 hours with the artificial placenta while maintaining fetal circulation. Dopamine could increase the mean arterial pressure transiently. However, blood lactatewas increased and the cardiac performance was gradually deteriorated over time even while the gas exchange ofthe artificial placenta was maintained. Elevated mean arterial pressurein our experiment might be achieved by systemic vasoconstriction, which led to decreased systemic organ flowdue to increased artificial placental flow, resulted in systemic circulatory failure. It may be important to retain both systemic and circuit circulation by controlling each resistance.