Association between γδT cells abnormalities and pathogensis in sarcoidosis.

结节病患者外周血γδ T细胞绝对数量、γδ T细胞比例及细胞表面CD 62 L、CD 69表达均无显著性差异。结节病患者外周血γδ T细胞亚群异常，Vγ2+细胞频率降低，Vγ9+细胞频率升高。PMA+离子霉素刺激后，部分患者γδ T细胞产生IFN-γ的能力增强。证实IFN-γ可诱导单核细胞增殖。γδ T细胞可能通过IFN-γ的异常产生而参与结节病的发病。

No significant differences in the absolute number of γδ T cells and the proportion of γδ T cells, and cell surface expression of CD62L and CD69 were observed in sarcoidosis patients. Abnormality of γδ T cells repertoire were observed ; the frequency of Vγ2+ cells was decreased and the frequency of Vγ9+ cells were increased in sarcoidosis patients compared to control. After the stimulation PMA plus ionomycin, γδ T cells from some patients have increased production of IFN-γ. It was confirmed that IFN-γ induced the proliferation of monocyte. γδ T cells may related to the pathogenesis of sarcoidosis by abnormal production of IFN-γ.