Association between γδT cells abnormalities and pathogensis in sarcoidosis.

γδT 细胞异常与结节病发病机制之间的关联。

• 批准号: 21791102
• 负责人: UEDA Ikuko
• 金额: $ 2.75万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791102/
• 关键词: 皮膚生理学; サルコイドーシス; γδT細胞

No significant differences in the absolute number of γδ T cells and the proportion of γδ T cells, and cell surface expression of CD62L and CD69 were observed in sarcoidosis patients. Abnormality of γδ T cells repertoire were observed ; the frequency of Vγ2+ cells was decreased and the frequency of Vγ9+ cells were increased in sarcoidosis patients compared to control. After the stimulation PMA plus ionomycin, γδ T cells from some patients have increased production of IFN-γ. It was confirmed that IFN-γ induced the proliferation of monocyte. γδ T cells may related to the pathogenesis of sarcoidosis by abnormal production of IFN-γ.

结节病患者中γδ T细胞绝对数量、γδ T细胞比例以及细胞表面CD62L和CD69表达均无显着差异。观察到γδ T细胞库异常；与对照组相比，结节病患者中 Vγ2+ 细胞的频率减少，Vγ9+ 细胞的频率增加。在 PMA 加离子霉素刺激后，一些患者的 γδ T 细胞产生了 IFN-γ 增加。已证实IFN-γ诱导单核细胞增殖。 γδ T细胞可能通过异常产生IFN-γ与结节病的发病有关。

项目成果

Reduced red blood cell velocity in nail-fold capillaries as a sensitive and specific indicator of microcirculation injury in systemic sclerosis

• DOI: 10.1093/rheumatology/kep066
• 发表时间: 2009-06-01
• 期刊: RHEUMATOLOGY
• 影响因子: 5.5
• 作者: Mugii, Naoki;Hasegawa, Minoru;Takehara, Kazuhiko
• 通讯作者: Takehara, Kazuhiko