Optimization of electroconvulsive therapy for drug-resistant depression based on neurotrophic factor dynamics as a prognostic factor

基于神经营养因子动力学作为预后因素的耐药性抑郁症电休克治疗的优化

• 批准号: 21791151
• 负责人: IKEDA Yumiko
• 金额: $ 2.66万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791151/
• 关键词: うつ病; ECT; 神経栄養因子; 電気痙攣療法

Level of serum brain-derived neurotrophic factor(BDNF) and Hamilton rating scale for depression symptoms were measured before, during and after electroconvulsive therapy(ECT) in patients with depression. Increased BDNF level was shown immediately after ECT, followed by improvement of the depressive symptoms. Increased BDNF level was maintained for 4 weeks after completion of ECT, while the depressive symptoms recurred 1 week after completion of ECT. These results show relationship between temporal dynamics of serum neurotrophic factor and severity of depressive symptoms induced by ECT.

测定抑郁症患者电休克治疗（ECT）前、中、后血清脑源性神经营养因子（BDNF）水平和汉密尔顿抑郁症状评定量表。电痉挛治疗后BDNF水平立即升高，随后抑郁症状改善。脑源性神经营养因子（BDNF）水平升高在ECT完成后维持4周，而抑郁症状在ECT完成后1周复发。这些结果表明，血清神经营养因子的时间动态与电休克引起的抑郁症状的严重程度有关。

项目成果

注意ネットワークに及ぼすカフェインの効果:薬理学的fMRI研究

咖啡因对注意力网络的影响：药理学功能磁共振成像研究

• 发表时间: 2012
• 作者: Takahashi;K.;et al.;池田裕美子
• 通讯作者: 池田裕美子

Reversal of hippocampal neuronal maturation by serotonergic antidepressants

• DOI: 10.1073/pnas.0912690107
• 发表时间: 2010-05-04
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Kobayashi, Katsunori;Ikeda, Yumiko;Suzuki, Hidenori
• 通讯作者: Suzuki, Hidenori

健常者における注意ネットワークに対するカフェインの効果:薬理学的fMRI研究

咖啡因对健康受试者注意力网络的影响：药理学功能磁共振成像研究

• 发表时间: 2011
• 作者: Takahashi;K.;池田裕美子
• 通讯作者: 池田裕美子