The structural change in the brain of the people with an At Risk Mental State(ARMS) for psychosis : the optimization of MR imaging for analysis

我们尝试使用基于体素的形态测量（VBM）和弥散张量成像（DTI）在1.5 T MRI下分析精神病高危精神状态（ARMS）患者的大脑结构变化。在第一次MR检查中，与正常对照相比，在ARMS患者中观察到部分脑萎缩，如内鼻皮层和扣带和额叶白质的DTI异常，但后来没有发展为精神病。结果表明易患精神病。

We tried to analyze the structural change in the brain of the people with an At Risk Mental State(ARMS) for psychosis by using Voxel based morphometry(VBM) and diffusion tensor imaging(DTI) at 1.5 T MRI. At the first MR examination, partial brain atrophy such as entorhinal cortex and DTI abnormalities in the cingulum and frontal white matter have been observed in the objects with an ARMS who did not develop psychosis later, compared with normal controls. The results suggested vulnerability to psychosis.