An early predictive biomarker of contrast-induced acute kidney injury

造影剂引起的急性肾损伤的早期预测生物标志物

• 批准号: 21791223
• 负责人: MANABE Kenichi
• 金额: $ 1.08万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791223/
• 关键词: 放射性医薬品.造影剤; 急性腎障害; 冠動脈造影; 造影剤; 放射性医薬品造影剤

Background :Urinary liver-type fatty acid-binding protein (L-FABP) is an intracellular carrier of free fatty acids, expressed in kidney proximal tubules. We examined whether urinary L-FABP is an early predictive biomarker of contrast-induced acute kidney injury (CI-AKI).Methods :We measured urinary L-FABP in 220 patients with creatinine (Cr)≧1.2 mg/dl (106 mol/l) scheduled for coronary angiography or angioplasty. Urinary L-FABP was measured before and after contrast agent administration.Results :CI-AKI developed in 19 patients (8.6%). There were no significant inter-group differences in serum Cr, estimated glomerular filtration rate, urinary N-acetyl-beta-D-glucosaminidase or β2-microglobulin (β2-MG) before contrast agent administration. The only significant pre-procedure difference was in L-FABP (17.7±33.3 vs. 49.8±53.6 ; P=0.005). At 24 and 48 hours post-procedure, all markers except urinaryβ2-MG differed significantly between the two groups. Multivariate analysis revealed L-FABP≧24.5 μg/g Cr (P<0.001 ; odds ratio [OR] : 9.10 ; 95% confidence interval [CI] : 3.20-28.9) and left ventricular ejection fraction≦40% (p=0.038 ; OR : 3.42 ; 95% CI : 1.07-10.8) to independently predict CI-AKI.Conclusions :Urinary L-FABP provides an important information for predicting CI-AKI after contrast agent administration

背景：尿肝型脂肪酸结合蛋白（L-FABP）是游离脂肪酸的细胞内载体，表达于肾脏近端小管。我们研究了尿L-FABP是否是造影剂诱导的急性肾损伤（CI-AKI）的早期预测生物标志物。方法：我们测定了220例肌酐（Cr）≤ 1.2 mg/dl（106 mol/l）的患者的尿L-FABP，这些患者计划进行冠状动脉造影或血管成形术。结果：19例患者（8.6%）发生CI AKI。造影剂给药前，血清Cr、估计肾小球滤过率、尿N-乙酰-β-D-氨基葡萄糖苷酶或β2-微球蛋白（β2-MG）无显著组间差异。唯一显著的术前差异是L-FABP（17.7±33.3 vs. 49.8±53.6 ; P=0.005）。术后24和48小时，除尿β2-MG外，两组间所有标志物均存在显著差异。多因素分析显示L-FABP为24.5 μg/g Cr（P<0.001 ;比值比[OR]：9.10 ; 95%置信区间[CI]：3.20-28.9），左室射血分数≥ 40%（p=0.038 ; OR：3.42 ; 95%CI：1.07-10.8）独立预测CI AKI。结论：尿L-FABP可作为预测CI AKI的重要指标

项目成果

L-FABP has been clinically recognized as a usefull biomaker For an early detection of kidney indury and long term suvival

L-FABP 已被临床认为是一种有用的生物标志物，用于早期检测肾损伤和长期生存

• 发表时间: 2010

L-FABP has been clinically recognized as a usefull biomaker for an eraly detection of kidney indury and long term suvival

L-FABP已被临床认为是一种有用的生物标志物，可用于早期检测肾损伤和长期生存

• 发表时间: 2010
• 作者: 真鍋憲市

Urinary liver-type fatty-acid-binding protein (L-FABP) could be an early predictive maker for impaired renal function after coronary angiography

尿肝型脂肪酸结合蛋白（L-FABP）可能是冠状动脉造影后肾功能受损的早期预测指标

• 发表时间: 2010