In vivo molecular neuroimaging for motor or cognitive dysfunction in non-human primate model of Parkinson's disease

用正电子发射计算机断层扫描(PET)检测重复MPTP处理的猕猴运动或认知功能与多巴胺能功能的关系。运动活动与腹外侧壳核中的多巴胺转运体结合显著相关，腹外侧壳核对应于从初级运动皮质接受运动输入的区域。这些结果表明，帕金森病模型中的特定功能缺陷是由纹状体亚区负责该功能的多巴胺能终末的变性引起的，这种退化程度取决于变性的程度。

Repeated MPTP-treated monkeys were examined relationship between motor or cognitive function and dopaminergic function by PET. Motor activity was significantly correlated with dopamine transporter binding specifically in the ventrolateral putamen, which corresponds to the area receiving motor inputs from the primary motor cortex. These results suggested that specific functional deficits in PD models were caused by degeneration of dopaminergic terminals in the striatal subregion responsible for that function in a manner dependent on the degree of degeneration.