Fundamental experiments for a quantitative myocardial blood flow measurement in 3D-PET

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Accuracy of quantitative myocardial blood flow(MBF) measurements using 3D-PET depends on activity distribution, especially outside filed-of-view(FOV) distribution. We investigated the influence on quantification of MBF by fundamental phantom experiments and a sophisticated Monte Carlo simulation. The effects of outside FOV activity were not critical for quantification of MBF. Especially, a MBF measurement by O-15 water was less insensitive to scatter originated from outside FOV activity.