Development of in-vivo dosimetry for proton beam therapy and application to a precise proton beam treatment plan

为了在质子治疗中进行体内剂量测量，我开发了一种即使在组织不均匀的情况下也能精确计算的剂量计算算法。我尝试使用金属氧化物-硅半导体场效应晶体管(MOSFET)探测器作为辐射探测器进行体内剂量测量，并改善了MOSFET探测器对线性能量转移(LET)效应的灵敏度劣化。在此基础上，提出了MOSFET探测器灵敏度劣化的修正方法，并建立了用该修正方法进行MOSFET探测器质子剂量测量的方法。

To perform in-vivo dosimetry in the proton beam therapy, I developed a dose calculation algorithm which can calculate precisely even in tissue heterogeneity. I tried the use of the metal oxide-silicon semiconductor field effect transistor (MOSFET) detector as a radiation detector for in-vivo dosimetry and improved sensitivity deterioration of the MOSFET detector for linear energy transfer (LET) effects. Furthermore, a correction method for sensitivity deterioration of the MOSFET detector was developed, and the proton dose measurements with the MOSFET detector by the correction method was established.