Molecular oncological study on lung cancer among atomic-bomb survivors

点击翻译按钮获取中文摘要

Risk of lung cancer among atomic-bomb(A-bomb) survivors remains high even now, more than 60 years after the bombings. However, the molecular mechanisms behind how radiation exposure influences the development of lung cancer have long remained unclear. Therefore, this study aimed to investigate the molecular oncological characteristics of lung cancer among A-bomb survivors by analyzing molecular alterations associated with lung carcinogenesis. In combination with our preliminary study, results obtained from this study suggest the possibility that molecular alterations such as frequencies of certain gene mutations and the types and DNA methylation may be associated with radiation exposure.