Development of new prophylactic reagent of hepatocellular carcinoma using thrombopoietin/platelets

本研究的目的是探索利用血小板生成素诱导血小板增多来预防肝细胞癌的新方法。我们阐明了促血小板生成素对肝癌细胞株的增殖没有影响。我们还研究了血小板生成素对Pten肝条件基因敲除小鼠肝细胞癌的预防作用。结果，促血小板生成素减少了雌性小鼠的肝细胞癌。血小板生成素对肝细胞癌有一定的预防作用。

The aim of this research is to develop new prophylactic method of hepatocellular carcinoma using thrombopoietin to induce thrombocytosis. We clarified that thrombopoietin has no effect of proliferating hepatocellular carcinoma cell lines. We also investigated the prophylaxis of hepatocellular carcinoma in Pten liver conditional knockout mice by administrating thrombopoietin. As a result, thrombopoietin reduce hepatocellular carcinoma in female mice. Thrombopoietin has some effect of prophylaxis of hepatocellular carcinoma.