Development of inhibitoin of intimal hyperplasia after bypass operation using siRNA mTOR

点击翻译按钮获取中文摘要

Rapamycin(sirolimus), initially developed as antibiotic and then as an immunosuppressant, has recently been used in drug-eluting stents to prevent restenosis. Rapamycin's cellular effects appear to be mediated through the intracellular protein target of rapamycin (TOR). The inhibitory effect of rapamycin on vascular smooth muscle cell proliferation has been well established. We examined whether the siRNA mTOR affects proliferation. siRNA mTOR decreased proliferation in vascular smooth muscle cells. siRNA mTOR could inhibit intimal hyperplasia.