Anigiogenic therapy using anaerobic bacterial vector in ischemic cardiovascular disease.

我们显示了全身或局部注射到缺血器官的长B.longum细菌的特异性积累，以及使用缺血后肢小鼠模型的非缺血器官和小型猪模型的心肌梗死中该细菌的消失。我们还显示，使用小鼠缺血模型，这种厌氧菌载体给药是普遍和局部安全的。使用B的厌氧载体。长杆菌可能是治疗缺血性心血管疾病患者新生血管的有效策略。

We showed the specific accumulation of B.longum bacterium injected generally or locally to ischemic organ, and the disappearance of this bacterium from nonischemic organ using ischemic hind limb mouse model, and in cardiac infarction in miniature swine model.We also showed that this anaerobic bacterial vector administration is generally and locally safe using mouse ischemic model. Anaerobic vector using B. longum bacterium may be an effective strategy for therapeutic neovascularization in patients with ischemic cardiovascular disease.