Mechanism of recurrence in hepatocel lular carcinoma after livertransplantation

本研究旨在阐明肝移植后肝转移的机制。采用小鼠脾注射模型作为门静脉微转移模型。所有小鼠都观察到宏观转移，但干扰素显著减少了肝转移的数量(19.3vs6.0，p&lt；0.05)。微血管密度用CD34免疫组织化学染色进行定量，与对照组相比，干扰素显著抑制血管生成。VCAM、ICAM等黏附分子的表达与干扰素治疗无关。

The aim of this study was to clarify the mechanism of liver metastasis after liver transplantation. Splenic injection model was used as micrometastasis setting via portal vein. Macroscopic metastasis was observed in all mice, but IFN administration significantly decreased number of liver metastasis (19.3 versus 6.0, p<0.05). Microvessel density was quantified using CD34 immunostaining and IFN significantly suppressed angiogenesis compared with control. Expression of adhesion molecules such as VCAM and ICAM did not correlate with IFN treatment.