Protective effect of antimicrobial peptides based on the beetle defensins on Artificial blood vessel infection

基于甲虫防御素的抗菌肽对人工血管感染的保护作用

• 批准号: 21791318
• 负责人: NACHI Sho
• 金额: $ 2.41万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791318/
• 关键词: 外科; 感染制御; 抗菌ペプチド

The Cecal ligation and puncture (CLP) model is a clinical septicemic and infection model. We gave antimicrobial peptide and examined effect of treatment on CLP model. Control group was CLP control group. Peptide group was injected intraperitoneally with antimicrobial peptides before closing the abdomen. In the peptide group, the survival days were significantly prolonged as compared with control group. IL-6 and TNF-α and endotoxin levels were low level in the peptide group than the control group. Thus, not only we significantly prolonged the survival days by the administration to CLP model, but also the antimicrobial peptide controlled inflammatory reaction, and there was thought to be effect of treatment.

盲肠结扎穿孔(CLP)模型是一种临床败血症和感染模型。我们给出了抗菌肽，并在CLP模型上检测了治疗效果。对照组为CLP对照组。多肽组在关腹前腹腔注射抗菌肽。多肽组小鼠存活天数较对照组明显延长。多肽组IL-6、肿瘤坏死因子-α和内毒素水平均低于对照组。由此可见，CLP模型不仅能明显延长小鼠的存活天数，而且抗菌肽对炎症反应有明显的控制作用，具有一定的治疗作用。

项目成果

盲腸穿刺腹膜炎モデルにおけるカブトムシから単離・改変された抗菌ペプチドの効果検討

从犀牛甲虫中分离和修饰的抗菌肽在盲肠穿刺腹膜炎模型中的作用研究

• 发表时间: 2010
• 作者: 守屋真紀雄;田村昌也;名知祥
• 通讯作者: 名知祥

カブトムシから単離・改変された抗菌ペプチドによる盲腸穿刺腹膜炎モデルにおける治療効果の検討

从犀牛甲虫中分离和修饰的抗菌肽在盲肠穿刺腹膜炎模型中的治疗效果研究

• 发表时间: 2010
• 作者: 守屋真紀雄;田村昌也;名知祥;名知祥;名知祥
• 通讯作者: 名知祥