Protective effect of antimicrobial peptides based on the beetle defensins on Artificial blood vessel infection

盲肠结扎穿孔（CLP）模型是一种临床败血症和感染模型。我们给药抗菌肽，并检查治疗对CLP模型的影响。对照组为CLP对照组。肽组于关腹前腹腔注射抗菌肽。与对照组相比，肽组的存活天数显著延长。IL-6、TNF-α和内毒素水平在肽组均低于对照组。因此，通过对CLP模型的给药，我们不仅显著延长了存活天数，而且抗菌肽控制了炎症反应，并且被认为具有治疗效果。

The Cecal ligation and puncture (CLP) model is a clinical septicemic and infection model. We gave antimicrobial peptide and examined effect of treatment on CLP model. Control group was CLP control group. Peptide group was injected intraperitoneally with antimicrobial peptides before closing the abdomen. In the peptide group, the survival days were significantly prolonged as compared with control group. IL-6 and TNF-α and endotoxin levels were low level in the peptide group than the control group. Thus, not only we significantly prolonged the survival days by the administration to CLP model, but also the antimicrobial peptide controlled inflammatory reaction, and there was thought to be effect of treatment.