Gene expression profiles associated with neurocognitive decline after aortic surgery under deep hypothermic circulatory arrest.

本研究探讨了深低温停循环主动脉手术后暂时性神经认知功能下降（NCD）的发生率以及与NCD相关的基因表达变化。主动脉手术后神经认知功能下降（NCD）发生率为60%。通过基因芯片分析比较手术前后血液样本中基因表达的变化。炎症和免疫反应相关基因表达的变化与深低温停循环主动脉手术后的NCD相关。

This study was examined incidence of temporary neurocognitive decline (NCD) and change in gene expression associated with NCD after aortic surgery utilizing deep hypothermic circulatory arrest. Neurocognitive decline (NCD) occurred at 60% after the aortic surgery. The change in gene expression between pre-and post-operative blood sample was compared by microarray analysis. Change in the gene expression involved in inflammatory and immune responses was associated with NCD after aortic surgery utilizing deep hypothermic circulatory arrest.