Basic research of photodynamic therapy for the malignant glioma using a newly photosensitizer.

新型光敏剂光动力治疗恶性胶质瘤的基础研究。

• 批准号: 21791346
• 负责人: SUGAWARA Kenichi
• 金额: $ 2.75万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791346/
• 关键词: 悪性神経膠腫; 光線力学療法; ポルフィリン誘導体

Various photosensitizers are used in a photodynamic therapy for human malignant gliomas. However, no satisfactory results are obtained because of low cytotoxicities. We experimented using a porphyrin derivative by silylation, which increased production efficiency of singlet oxygen with cytotoxicity compared with other photosensitizers. Photodynamic therapy of human malignant gliomas using this newly photosensitizer may be possible.

各种光敏剂被用于人类恶性胶质瘤的光动力疗法。然而，由于细胞毒性低，结果并不令人满意。我们通过硅烷化反应实验了一种卟啉衍生物，与其他光敏剂相比，它提高了具有细胞毒性的单线态氧的生产效率。使用这种新型光敏剂对人类恶性胶质瘤进行光动力学治疗是可能的。