Molecular mechanisms involved in intervertebraldisc degeneration and potential new treatment strategies

本研究的目的是研究β1,3-葡萄糖醛酸基转移酶i （GlcAT-I）的表达和调控，GlcAT-I是调节椎间盘细胞中GAG合成的关键酶。体内髓核中glcat - 1有较强的表达。我们证明钙调节glcat - 1的表达，glcat - 1是通过TonEBP/NFAT5和Cn-NFAT信号通路合成GAG所需的关键酶。

The goal of this investigation was to study the expression and regulation of β1,3-Glucuronosyltransferase-I (GlcAT-I), a key enzyme regulating GAG synthesis in cells of the intervertebral disc. There was a robust expression of GlcAT-I in the nucleus pulposus in vivo. We demonstrate that calcium regulates expressionof GlcAT-I, a critical enzyme required for GAG synthesis through TonEBP/NFAT5 and Cn-NFAT signaling pathways.