Research of adiponectin in the pathogenesis of rheumatoid arthritis

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Rheumatoid arthritis is an intractable disease that causes progressive joint destruction. The pathogenesis of rheumatoid arthritis is still unknown. We examined the concentrations of the adiponectin secreted by the adipose cell that is considered to be a beneficial cytokine in metabolic syndrome. Although there is no difference in the concentration of serum adiponectin between rheumatoid arthritis patients and osteoarthritis patients, the concentration of intraarticular synovial adiponectin was higher in rheumatoid arthritis patients than in osteoarthritis patients. The adiponectin was thought to play some role in joint inflammation of patients with rheumatoid arthritis.