Research of adiponectin in the pathogenesis of rheumatoid arthritis

脂联素在类风湿性关节炎发病机制中的研究

• 批准号: 21791421
• 负责人: IWAMOTO Takuji
• 金额: $ 2.75万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791421/
• 关键词: 関節リウマチ; アディポネクチン; 脂質代謝; 関節液

Rheumatoid arthritis is an intractable disease that causes progressive joint destruction. The pathogenesis of rheumatoid arthritis is still unknown. We examined the concentrations of the adiponectin secreted by the adipose cell that is considered to be a beneficial cytokine in metabolic syndrome. Although there is no difference in the concentration of serum adiponectin between rheumatoid arthritis patients and osteoarthritis patients, the concentration of intraarticular synovial adiponectin was higher in rheumatoid arthritis patients than in osteoarthritis patients. The adiponectin was thought to play some role in joint inflammation of patients with rheumatoid arthritis.

风湿性关节炎是一种顽固性疾病，导致关节进行性破坏。类风湿关节炎的发病机制尚不清楚。我们检测了脂肪细胞分泌的脂联素的浓度，脂联素被认为是代谢综合征中的有益细胞因子。虽然类风湿性关节炎患者和骨关节炎患者的血清脂联素浓度没有差异，但类风湿性关节炎患者的关节滑液脂联素浓度高于骨关节炎患者。脂联素被认为在类风湿关节炎患者的关节炎症中起一定作用。

项目成果

関節リウマチ患者における血清アディポネクチン濃度

类风湿性关节炎患者血清脂联素浓度

• 发表时间: 2010
• 作者: 廣島亮;岩本卓士;ほか
• 通讯作者: ほか