Regulation of osteoclastogenesis by transcriptional repressors

据报道，破骨细胞分化的转录调控涉及激活负责破骨细胞形成和功能的基因的表达。我们发现Bcl6和Blimp1这两个转录抑制因子对破骨细胞的分化是必不可少的。结果表明，Bcl6抑制未分化破骨细胞前体的破骨形成，Blimp1在破骨细胞因子RANKL刺激下，在转录水平抑制Bcl6，促进破骨细胞分化。Blimp1-Bcl6轴在调节破骨细胞生成中起关键作用。

Transcriptional regulation in osteoclast differentiation was reportedly involved in activating expression of genes which were responsible for osteoclast formation and functions. We found that two transcription repressors, Bcl6 and Blimp1, were essential for osteoclast differentiation. Our data evidenced that Bcl6 repressed osteoclastogenesis in undifferentiated osteoclast precursors, and Blimp1 promoted osteoclast differentiation through suppressing Bcl6 at the transcriptional level under stimulation by osteoclastogenic cytokine, RANKL. The Blimp1-Bcl6 axis is crucial to regulate osteoclastogenesis.