The effect of tumor secreting physiologically active substances for synaptic transmission.

许多研究表明，肿瘤分泌生理活性物质对电压依赖的钠通道For NAV1.3的表达是癌痛发生的机制之一。本研究的目的是利用大鼠背根神经节(DRG)神经元，研究肿瘤分泌的生理活性物质对电压依赖性钠通道表达的影响。结果：NAV1.3主要表达于神经生长因子和肿瘤坏死因子-α。结论：肿瘤组织分泌神经生长因子、肿瘤坏死因子-α等生理活性物质可能是癌性疼痛的原因之一。

Many studies have indicated that the expression of for NaV1.3 a kind of voltage-dependent sodium channels by tumor secreting physiologically active substances is one of the mechanisms of cancer pain. The aim of this study was to invest the effect of tumor secreting physiologically active substances for expression of voltage-dependent sodium channels by using Rat dorsal root ganglion (DRG) neurons. Results : NaV 1.3 was most expressed by NGF and TNF-α. Conclusion : NaV1.3 expression by tumor secreting physiologically active substances such as NGF and TNF-α may be one of the causes of cancer pain.