The effect of tumor secreting physiologically active substances for synaptic transmission.

肿瘤分泌生理活性物质对突触传递的影响。

• 批准号: 21791458
• 负责人: KASHIWADA Masatoshi
• 金额: $ 2.91万
• 依托单位: University of Miyazaki
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791458/
• 关键词: リドカイン; アポトーシス; 腫瘍特異性; 水棲カタツムリ; exocytosis; NGF; EPSP; MEPPs

Many studies have indicated that the expression of for NaV1.3 a kind of voltage-dependent sodium channels by tumor secreting physiologically active substances is one of the mechanisms of cancer pain. The aim of this study was to invest the effect of tumor secreting physiologically active substances for expression of voltage-dependent sodium channels by using Rat dorsal root ganglion (DRG) neurons. Results : NaV 1.3 was most expressed by NGF and TNF-α. Conclusion : NaV1.3 expression by tumor secreting physiologically active substances such as NGF and TNF-α may be one of the causes of cancer pain.

许多研究表明，肿瘤分泌生理活性物质引起的电压依赖性钠通道（NaV1.3）的表达是癌痛的机制之一。本研究的目的是利用大鼠背根神经节（DRG）神经元研究肿瘤分泌的生理活性物质对电压依赖性钠通道表达的影响。结果：NaV1.3主要由NGF和TNF-α表达。结论：肿瘤组织分泌的生理活性物质如NGF、TNF-α表达NaV 1. 3可能是癌痛的原因之一。

项目成果

Lidocaine depolarizes the mitochondrial membrane potential by intracellular alkalization in rat dorsal root ganglion neurons

• DOI: 10.1007/s00540-010-1079-y
• 发表时间: 2011-04-01
• 期刊: JOURNAL OF ANESTHESIA
• 影响因子: 2.8
• 作者: Onizuka, Shin;Yonaha, Tetsu;Tsuneyoshi, Isao
• 通讯作者: Tsuneyoshi, Isao

Tsuneyosh I.Lidocainedepolarizes the mitochondrial membranepotential by initracellularalkalization in rat dorsal root ganglion neurons

Tsuneyosh I.利多卡因通过细胞内碱化大鼠背根神经节神经元的线粒体膜电位

• 发表时间: 2011
• 期刊: J Anesth 25(2)
• 作者: onizuka S;Yon T;ra R;KasiwadaM;Shirasaka T
• 通讯作者: Shirasaka T

Capsaicin Indirectly Suppresses Voltage-Gated Na+ Currents Through TRPV1 in Rat Dorsal Root Ganglion Neurons

• DOI: 10.1213/ane.0b013e318204ea5b
• 发表时间: 2011-03-01
• 期刊: ANESTHESIA AND ANALGESIA
• 影响因子: 5.7
• 作者: Onizuka, Shin;Yonaha, Tetsu;Tsuneyoshi, Isao
• 通讯作者: Tsuneyoshi, Isao