The mechanisms of cytokine-induced encephalopathy and influence on anesthesia

细胞因子脑病的发生机制及对麻醉的影响

• 批准号: 21791461
• 负责人: HAYASHI Shiho
• 金额: $ 1.91万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791461/
• 关键词: サイトカイン; アセチルコリン; 催眠作用; 感染症; リポポリサッカライド; 敗血症; マイクロダイアリーシス

I conducted research to confirm if cytokine levels affect acetylcholine neuron. Lipopolysaccharide was injected to rats intraperitoneally. Microdialysis probe was inserted into brain and samples were obtained. The acetylcholine levels were measured using HPLC system. Our results showed that the extracellular acetylcholine levels of rat brain after LPS injection were not significantly different from control levels.

我进行了一项研究，以确认细胞因子水平是否会影响乙酰胆碱神经元。大鼠腹腔注射脂多糖。将微透析探头插入脑内，取标本。用高效液相色谱仪测定乙酰胆碱水平。结果表明，注射脂多糖后，大鼠脑组织细胞外乙酰胆碱水平与对照组无显著差异。