Elucidation of anti-inflammatory effect of local-anesthetic

局麻药在血液和组织中浓度的定量是评价局麻药抗炎作用的必要条件。因此，我们建立了一种利用微透析技术定量测定局麻药浓度的方法。三种麻醉药的脑血药浓度比值无差异，但布比卡因的脑细胞外液浓度与血浆游离分数比值显著高于利多卡因和左旋布比卡因。

It isnecessary forelucidation of anti-inflammatory effect of local anesthetic to the quantification of the concentration of the local anesthetics in the blood and in the tissue. So we established the method of the he quantification of the concentration of the local anesthetics by microdialysis using the retrodialysis calibration method. No differences in the ratio of total brain concentration to total plasma concentration among the three anesthetics, butthe ratio of cerebral extracellular fluid concentration to plasma unbound fraction of bupivacaine was significantly higher than lidocaine and levobupivacaine.