The effect of volatile anesthetics for the myocardial microperfusion in systolic and diastolic phase.

挥发性麻醉药对收缩期和舒张期心肌微灌注的影响。

• 批准号: 21791472
• 负责人: NEGORO Takaaki
• 金额: $ 2.41万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791472/
• 关键词: 揮発性吸入麻酔薬; 動的心筋内微小潅流; 動的心筋内微少潅流

The myocardium that is the muscle of the heart has repeated contraction and relaxation continuously. In order to reveal the action of the volatile anesthetic to the microvessel which supplies blood to the myocardium, we sliced the cardiac muscle of the rat and observed the myocardial microvessel how vessel diameter would change under the influence of vasoactive drugs and volatile anesthetics. Although the capillary vessels in a myocardium showed the contraction under the vasoconstrictor drug, the stable relaxation response by a vasodilator drug was not observed. It was thought that the method of study was unsuitable.

心肌是心脏的肌肉，具有不断重复的收缩和舒张。为了揭示吸入麻醉药对心肌微血管的作用，我们将大鼠心肌切片，观察了在血管活性药物和吸入麻醉药作用下心肌微血管直径的变化。虽然心肌中的毛细血管在血管收缩药物下显示收缩，但未观察到血管扩张药物的稳定舒张反应。人们认为这种研究方法不合适。