课题基金 / 基金详情

PPARγ agonist rosiglitazone attenuates the development of neuropathic pain by regulating macrophage activation.

PPARγ agonist rosiglitazone attenuates the development of neuropathic pain by regulating macrophage activation.
PPARγ 激动剂罗格列酮通过调节巨噬细胞活化来减轻神经性疼痛的发展。
批准号:
21791476
负责人:
TAKAHASHI Yoshika
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

项目摘要

项目成果

TAKAHASHI Yoshika的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Neuroinflammation triggered by macrophage infiltration into sites of peripheral nerve injury may result in neuropathic pain. Peroxisome proliferator-activated receptor gamma(PPARγ) signaling regulates the properties of macrophages. So we investigated the macrophage-mediated effects of PPARγ signaling on neuropathic pain triggered by peripheral inflammation using have not been partial sciatic nerve ligation (PSNL) mice model. PPARγ treatment in the early phase of neuropathic pain significantly alleviated the development of tactile allodynia by regulating macrophage infiltration and production of proinflammatory molecules at the inflamed site. Our results indicate that the activation of PPARγ signaling in macrophages during the early phase may suppress neuropathic pain development.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
PPARγ agonist rosiglitazone attenuates the development of neuropathic pain by regulating macrophage activation.
PPARγ 激动剂罗格列酮通过调节巨噬细胞活化来减轻神经性疼痛的发展。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Takahashi Y, Hasegawa-Moriyama M, Inada E, Sakurai T, Yoshika Takahashi]
通讯作者: Yoshika Takahashi
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Takahashi Y, Hasegawa-Moriyama M, Inada E, Sakurai T, Yoshika Takahashi, 高橋良佳]
通讯作者: 高橋良佳
The Macrophage-Mediated Effects of the Peroxisome Proliferator-Activated Receptor-Gamma Agonist Rosiglitazone Attenuate Tactile Allodynia in the Early Phase of Neuropathic Pain Development
过氧化物酶体增殖物激活受体-γ 激动剂罗格列酮的巨噬细胞介导作用可减轻神经病理性疼痛发展早期的触觉异常性疼痛
DOI: --
发表时间:
期刊: Anesth Analg, peer-reviewed in press
影响因子: --
作者: [Takahashi Y, Hasegawa-Moriyama M, Inada E, Sakurai T]
通讯作者: Sakurai T
慢性神経因性疼痛におけるrosiglitazoneのマクロファージを介した鎮痛作用の解析
罗格列酮巨噬细胞介导的慢性神经病理性疼痛镇痛作用分析
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Takahashi Y, Hasegawa-Moriyama M, Inada E, Sakurai T, Yoshika Takahashi, 高橋良佳, 高橋良佳]
通讯作者: 高橋良佳
Prevention and risk factors identification of early intervention in persistent pain after thoracotomy.
  • 批准号:
    26460612
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.58万
  • 财政年份:
    2014
  • 负责人:
    TAKAHASHI Yoshika
  • 依托单位:
海外基金