PPARγ agonist rosiglitazone attenuates the development of neuropathic pain by regulating macrophage activation.

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Neuroinflammation triggered by macrophage infiltration into sites of peripheral nerve injury may result in neuropathic pain. Peroxisome proliferator-activated receptor gamma(PPARγ) signaling regulates the properties of macrophages. So we investigated the macrophage-mediated effects of PPARγ signaling on neuropathic pain triggered by peripheral inflammation using have not been partial sciatic nerve ligation (PSNL) mice model. PPARγ treatment in the early phase of neuropathic pain significantly alleviated the development of tactile allodynia by regulating macrophage infiltration and production of proinflammatory molecules at the inflamed site. Our results indicate that the activation of PPARγ signaling in macrophages during the early phase may suppress neuropathic pain development.