Comprehensive research on epigenetics in male infertility

男性不育症表观遗传学综合研究

• 批准号: 21791496
• 负责人: MAEDA Yuji
• 金额: $ 2.33万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791496/
• 关键词: エピジェネティックス; 精子形成

The gene expression is selectively controlled. The individuality of the cell is determined by combination of activated genes so that it makes the physiological functions as the entire individual. Epigenetics is taking part as one of the control mechanisms of gene expression. Recent reports showed that epigenetic control is important in embryology or oncology. In mammalian spermatogenesis, spermatogenic cells develop into functional gametes through meiosis with complex gene expression. Our study suggested that certain genes important in spermatogenesis are involved in epigenetic control of its expression.

基因的表达受到选择性控制。细胞的个体性是由激活的基因组合决定的，因此它作为整个个体发挥生理功能。表观遗传学是基因表达调控机制之一。最近的报告表明，表观遗传控制在胚胎学或肿瘤学中很重要。在哺乳动物精子发生过程中，生精细胞通过减数分裂发育为功能性配子，伴随着复杂的基因表达。我们的研究表明，某些基因在精子发生中的重要参与其表达的表观遗传控制。

项目成果

Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in thetestis.

人类 VASA 基因的组织特异性差异甲基化区域可能与睾丸成熟停滞表型相关。

• 发表时间: 2009
• 期刊: J Hum Genet 54
• 作者: Sugimoto K;Koh E;Sin HS;Maeda Y;Narimoto K;Izumi K;Kobori Y;Kitamura E;Nagase H;Yoshida A;Namiki M.
• 通讯作者: Namiki M.

Impact ofaberrant ALF gene methylation onoutcome of testicular sperm extractionand intracytoplasmic sperm injection

ALF基因甲基化异常对睾丸取精和胞浆内单精子注射结果的影响

• 发表时间: 2009
• 作者: Kazuhiro Sugimoto;Kouji Izumi;Kazutaka Narimoto;Sotaro Miwa;YujiMaeda;Tohru Miyagi;Jiro Kanaya;Yasuhide Kitagawa;Yoshihumi Kadono;Hiroyuki Konaka;Atsushi Mizokami ,Eitetsu Koh;Mikio Namiki
• 通讯作者: Mikio Namiki

Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis

人类 VASA 基因的组织特异性差异甲基化区域可能与睾丸成熟停滞表型相关

• 发表时间: 2009
• 期刊: Journal of Human Genetics 54
• 作者: Kazuhiro Sugimoto;Eitetsu Koh;Ho-Su Sin;Yuji Maeda;Kazutaka Narimoto;Koji Izumi;Yoshitomo Kobori;Eiko Kitamura;Hiroki Nagase;Atsumi Yoshida;Mikio Namiki
• 通讯作者: Mikio Namiki

TESE-ICSIがDNAメチル化異常による精子形成障害を治療できる可能性

TESE-ICSI 治疗 DNA 异常甲基化引起的精子发生障碍的可能性

• 发表时间: 2009
• 作者: 杉本和宏;申湖水;前田雄司;金谷二郎;高栄哲;並木幹夫;吉田淳;北村栄子;永瀬浩喜
• 通讯作者: 永瀬浩喜