Effect of androgen receptor on apoptosis induction in androgen- independent prostate cancer cells
Effect of androgen receptor on apoptosis induction in androgen- independent prostate cancer cells
批准号:
21791514
负责人:
IGUCHI Kazuhiro
金额:
$1.66万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
Low-androgen-sensitive LNCaP-E9 cells and androgen-independent AIDL cells were established from androgen receptor-positive prostate cancer LNCaP cells. Androgen receptor was expressed in LNCaP-E9 and AIDL cells. Low androgen sensitivity in LNCaP-E9 cells was associated with reduced Akt phosphorylation. W741C and T877A mutations were found in AIDL cells and the mutations may explain the androgen resistance of AIDL cells.
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Pamidronate inhibits anti-apoptotic bcl-2 expression through inhibition of the mevalonate pathway in prostate cancer PC-3 cells.
Pamidronate 通过抑制前列腺癌 PC-3 细胞中的甲羟戊酸途径来抑制抗凋亡 bcl-2 的表达。
DOI:
--
发表时间:
2010
期刊:
Eur.J.Pharmacol. 641
影响因子:
--
作者:
[Iguchi, K., Tatsuda, Y., Usui, S., Hirano, K.]
通讯作者:
K.
DOI:
10.2164/jandrol.110.011205
发表时间:
2011-03-01
期刊:
JOURNAL OF ANDROLOGY
影响因子:
--
作者:
[Iguchi, Kazuhiro, Morihara, Naoaki, Hirano, Kazuyuki]
通讯作者:
Hirano, Kazuyuki
Evidence that androgen-independent stromal growth factor signals promote androgen-insensitive prostate cancer cell growth in vivo.
有证据表明,不依赖雄激素的基质生长因子信号可促进体内雄激素不敏感的前列腺癌细胞生长。
DOI:
--
发表时间:
期刊:
Endocrine-Related Cancer (in press)
影响因子:
--
作者:
[Ishii K, Imamura T, Iguchi K, Arase S, Yoshio Y, Arima K, Hirano K, Sugimura Y.]
通讯作者:
Sugimura Y.
Characterization of androgen-low sensitive LNCaP subline, LNCaP-E9 cells
雄激素低敏感 LNCaP 亚系 LNCaP-E9 细胞的表征
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kazuhiro Iguchi, Kazuhiro Fukami, Kenichiro Ishii, Shigeyuki Usui, Yoshiki Sugimura, Kazuyuki Hirano]
通讯作者:
Kazuyuki Hirano
Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells.
前列腺癌 PC-3 细胞中的蛋白激酶 C 被双磷酸盐抑制。
DOI:
--
发表时间:
2010
期刊:
Eur.J.Pharmacol. 627
影响因子:
--
作者:
[Tatsuda, Y., Iguchi, K., Usui, S., Suzui, M., Hirano, K.]
通讯作者:
K.
共 6 条
Characterization of the low pH-resistant LNCaP cell subline
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批准号:23791768
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.33万
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财政年份:2011
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负责人:IGUCHI Kazuhiro
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依托单位: